How Long Does It Take For HRT To Work?

Some posts here on ARoseTintedWorld may contain affiliate links. This means that if you click a link and buy a product or register, then I may receive a commission at no extra cost to you. I may also use products from the companies mentioned in these posts. Thank you for supporting my blog!

Just recently I decided to try hormone replacement therapy to see whether my perimenopause/menopause symptoms would improve. But how long does it take for HRT to work? How long after starting HRT do you feel a difference? Here is what I have found.

How Long Does It Take For HRT To Work?


Are you a woman in her 40s or 50s with a whole load of symptoms that you cannot explain? Well, it may be that you are peri-menopausal/menopausal and are lacking in the oestrogen, testosterone and progesterone that you need. As we reach peri menopause, these hormone levels start to decrease in the body, leading to all sorts of symptoms, which can vary from woman to woman.

But how long does it take HRT to start working? This does depend on what symptoms you have prior to starting taking HRT, the dosages that you receive, and the delivery method. The severity of your symptoms will affect how long until HRT works for you.

What Are The Symptoms Of Perimenopause and Menopause?

Menopause is not just a lack of periods, night sweats and hot flushes! In fact I have never really had a hot flush yet. Menopause is when you finally cease to have periods. In fact you are not classed as being in menopause until you have not had a period for 12 months.

But there are lots of other symptoms of perimenopause, and you can start experiencing menopausal symptoms a full 10 years before the actual menopause happens. During perimenopause a hormone imbalance starts to occur, which can really affect your body and mind.

Nobody really talks about these symptoms, and GPs don’t always think about them holistically. As I found, my GP treated just the symptoms I was getting, and didn’t consider my full body was going through changes. 

So Are You Experiencing Menopausal Symptoms?

Here are the menopausal symptoms to watch out for.

  • Anxiety 
  • Depression
  • Loss of libido / low sex drive
  • Fatigue
  • Body aches
  • Weight gain – or inability to achieve any kind of weight loss
  • Hair loss
  • Itchy skin
  • Mood swings
  • Night sweats
  • Irritability
  • Brain Fog / forgetfulness 
  • Dizzy spells
  • Lack of motivation
  • Acne
  • Palpitations
  • Irregular periods
  • Hot flushes
  • Vaginal dryness

So my advice would be to discuss all these with your doctor once you start experiencing them, and ask at that point if starting HRT is worthwhile for you at that point. 

My Own Hormonal Imbalance Symptoms and Experience 

I have been suffering the effects of the peri-menopause for quite a while, since I turned 40 if I am totally honest. But some of my own symptoms were taking over my life.

Even before I got pregnant at 43 years old, my periods were slightly more erratic. Strangely, after having a baby, my periods got a little more regular for a few years. But then the irregular periods began again. I struggled with weight loss, and my weight just kept rising.

A lot of the time I felt fatigued, even though my sleep had actually improved. I had a lot of mood swings and struggled to stay active. My low mood was really affecting my life and relationships.

Although I have always suffered a little with anxiety and depression, my anxiety became overwhelming. And this was before the pandemic hit, so you can imagine how much worse my mental health suffered became once that arrived.

I started with terrible palpitations just after the pandemic started. Now, I am still not sure that these palpitations were all menopause related. I could have an element of long covid too. My heart was checked out extensively and no damage was found. The palpitations reduced slightly but were still there. Which made me wonder if the palpitations were maybe now menopause related. Palpitations are one of the lesser known menopause symptoms. I asked my GP.

And really got the brush off.

I had 2 ambulatory ECG tests and they ruled out any heart disease. But I also asked my GP if it could be menopause. Even though I was suffering with the palpitations and they were giving me distress and anxiety, the GP didn’t really listen or suggest anything other than putting me on heart drugs and indigestion tablets. Even when I asked outright if it was menopause I got no answer, was told to keep taking the drugs prescribed.

And I Knew Others Going Through Similar Fights

I knew of other women who had also gone to their GP when having perimenopause symptoms, only to be given the run around. My sister in law had been anxious for a while, and was suffering what she called ‘brain fog’. She felt like she couldn’t remember what she should be doing, forgot simple tasks and found it very hard to concentrate. 

Her GP gave her antidepressants. But as my SIL’s symptoms worsened, the GP just kept upping the dose of antidepressants. She was on a huge dosage.

It took a visit to the hospital for them to finally agree to her taking HRT. And by the time this was needed my SIL had suffered from other menopausal symptoms for years.

Once I heard that she had been offered HRT I decided to ask my doctor about hormone therapy again.

I Rang My GP Clinic Once More

And was told that I should “think about what I wanted”…?!

I felt a bit horrified at this. Surely a GP is there to advise, not just to tell you to ‘go do your research’? But my anger was going to spur me to read up more about HRT, and what it entails.

Strangely, right at the same time I read this article by a lady who sounded like she had really been suffering too with a lot of perimenopause symptoms, and had also been refused treatment. She had tried bioidentical hormone therapy, which she found useful for a couple of months, but then she found that the bioidentical hormone replacement drugs were from unlicensed pharmacies. She tried her own GP and found that they were a little unhelpful.

In her article she spoke about the “Gold Standard” HRT treatment being Oestrogen gel or patches, Micronised Progesterone, and Testosterone should you need it. She had finally managed to get this care, and now was part of the team making a medical documentary about HRT that was due to be aired on Channel 4 and fronted by Davina McCall. 

She suggested going to a menopause website to read up more about the issue before tackling your GP for a new treatment plan.

So I would certainly suggest the you do the same. is a great place to get some answers. As is the NHS website, and Menopause matters

  • Write down the symptoms you are suffering with
  • Look up your family history. Is there any history of blood clots or breast cancer?
  • Jot down questions to ask your GP – ask if your symptoms could be due to menopause and if you need any other investigations?

But also be ready to be quite assured with your doctor. As I found that my GPs really weren’t going to just give me hormones without my being quite definite.

What To Expect As A Patient When You Visit Your Doctor or GP

I went in with all my info and symptoms and firmly told the GP what I wanted.

They took a full medical history, asked me a lot of family history questions, and asked questions about my lifestyle.

You may need a blood test. On the strength of my recent blood test my doctor decided to give me estrogen gel and micronised progesterone, just as I wanted. I know some patients may need or prefer the patches type of oestrogen.

We discussed the increased risk of blood clots with HRT, and discussed breast cancer risks. 

How To Take HRT

When I asked how long does it take for HRT to start working my GP told me that the HRT would take a couple of weeks to get into my system. She told me that the progesterone (Utrogestan) would make me feel drowsy, so to take it at night.

I started using the Oestrogel gel for menopause the morning after I collected it from the pharmacy. I always have a shower on a morning. And so I dried off well and placed a thin layer of oestrogen into my upper arms before letting it dry.


How Long For HRT To Start Working – The First Week

How long did it take for the HRT to work for me? Certainly the progesterone tablets knocked me out at first. I immediately saw a change in how well I was sleeping.

How long does it take for estrogen to work? Even though the doctor had said that I wouldn’t feel much if a change for a couple of weeks, I did feel much better even on the first day. Maybe it was a placebo effect, maybe it was the thought that something could get better. But I straight away had more energy and felt that I could do more.

Although my back and sciatica pain did not go away, there also was a little bit of an improvement there. The whole general feeling of being less apathetic meant that I felt inspired to do my physio exercises every day too. There were certainly signs HRT is working.


HRT Side Effects

A few days after I started the HRT, I did notice a couple of side effects starting. I had a bad headache and felt sick after about day 5 of HRT. But then it did improve after day 8. This sickness and headaches kept coming and going again over the first few weeks

My GP had advised me to stop taking the HRT if I felt any of the more severe side effects. There is no ‘one size fits all’ to HRT, it may be that I need my hormone levels checking and to see what I needed. But I still felt better, so I carried on.


Then, after the second week, I seemed to suffer a bit of a relapse. You are only meant to take the progesterone for 14 days and then have a 14 day break. But just before I had the progesterone break, I really started to feel tired and achy once more. 

My partner said I was not as cranky and moody as before, but I still felt pretty lousy, and back to feeling fatigued at the slightest thing. 

And my first period which came a few days after stopping the progesterone was the most painful one that I had had for a long while. My tummy ached, I felt hot and bothered, and just felt like curling up in a ball and sleeping.

After this initial couple of weeks though, things have just improved again and I feel much more my old self. I do seem to have much more energy, and feel like tackling the world once more. I certainly know that my mood has improved, and I have fewer palpitations, even if they have not completely gone yet.


How Long Can You Take HRT For?

As I said before, it is worth having that conversation with a medical professional early on in your perimenopause journey, or at least when you feel that your symptoms are getting the better of you.

Can you take HRT for the rest of your life? Well, there isn’t a limit to the length of time you can take it for, but most women find that they can stop taking HRT a few years after the menopause, or once symptoms have lessened enough. 

How long do you take HRT for therefore depends person to person on the symptoms you personally are suffering. And you should keep discussing this with your medical practitioner.

Is There Other Help Out There?

I’ve since joined a facebook group for menopausal sufferers, and have found that a lot of people say that they started HRT and feel awful for a while before they start to feel better. How long for HRT to work varied from person to person. Some women say that it took up to 6 weeks for them to see the benefits of HRT patches, pills or gel. Whilst others found that there were more benefits of HRT patches (oestrogen patches) than gel. 

Every woman is different, and most people need regular follow ups with the GP to ensure that the HRT is working as it should. 

So How Long Did It Take For HRT To Work For Me?

I am slowly starting to feel so much better and know that hormone therapy works for me. It took about 3-4 weeks for HRT to start working for me. And should it seem that  there are signs HRT is not working, I will just need to discuss with my GP again whether to try a HRT patch instead of oestrogen gel, or maybe discuss whether I also need testosterone supplements too.


I hope that this has helped. Are you suffering from any of these symptoms? Does Hormone therapy work for you? How long did it take for HRT to work for you?

I’d love to hear your comments. Write something below, or why not find me on my social media channels and we can carry on the discussion there.

And please do pin this post for later.

How Long Does It Take For HRT To Work? Are you a woman in your 40s or 50s suffering symptoms? Here is my experience of starting HRT therapy.

15 Replies to “How Long Does It Take For HRT To Work?”

  1. Michelle says:

    Hi Jo,

    I’m 51. In January I had an U/S scan which showed thickening of my womb lining, fibroids and probable polyps so I was referred for a hysteroscopy and biopsy which I had in April. The consultant inserted a Mirena to help with my horrendously heavy and painful periods which had made me anaemic 3 times in 3 years. Thankfully the biopsy came back clear. So with the anaemia, I was mostly always tired anyway. And my periods only started to lose their 100% regularity in January. I was actually praying to go into my menopause. But looking back I did have other symptoms of peri menopause such as brain fog and always needing to wee at night. I had aches and pains but I put that down to injuries I sustained in a fall in late 2019, and then how my physio was abruptly cancelled due to Covid. I’d had the Mirena years ago but after 4 years, had it removed due to constant spotting and lack of libido. I only agreed to have it inserted again because my periods were a nightmare and I had no libido anymore anyway.. again another possible sign of peri menopause. When I mentioned the libido issue to the hysteroscopy consultant, she suggest I try estrogel, as the Mirena acts as the progesterone part of HRT. So about 2 months later I asked to be prescribed the estrogel and have now been using it for 4 weeks, 2 pumps a day. There has been no dramatic transformation. I never had night sweats so that hasn’t changed. I think I feel a bit more sharp in my thinking again. I have slept through the night twice this week which is new. I think my libido is slightly higher. That’s about it so far. But I’ll take any positive change and be glad of it. After 6 weeks of bleeding, at times heavy, the Mirena seems to have worked. Only occasional spotting now. So not having periods alone will improve my quality of life significantly. Anyway, it is early days and it might show more benefits over time. It has also occurred to me it might prevent symptoms I had in store, like night sweats. Overall pleased.

    1. Jo Boyne says:

      Thank you for sharing your story. I will admit that I have had ups and downs with HRT since I started a couple of months back, but the general trend seems to be improvement. I hope that you feel better and better too!

      1. Rebecca says:

        I really enjoyed reading your story thank you. I’m 45 yrs old and I started on combined patches 2 weeks ago. I’m still having night sweats but it’s early days. However, my mood has lifted already and I feel less irritated. Time will tell if my heavy painful periods improve. I’ve had no side effects at all so for me so far so good.

        1. Jo Boyne says:

          That is good to hear. My mood improved too and I hope you continue to see great results!

  2. Sharon says:

    I am taking the exact same combo as you. I am interested in taking the testosterone sups but can you get this from your Gp?

    Brilliant article

    Thank you

    1. Jo Boyne says:

      From what I gather you do need to ask your GP for testosterone.And you may need to go to a private consultant. I have heard it is helpful with low libido. And I have also heard that most GPs are reticent to prescribe it.

      1. Tanya says:

        Hi. I’m 51. I’ve had many symptoms for several years and been feeling like I must have some underlying illness.
        After having such heavy periods that I became seriously anaemic I had the mirena coil fitted. I’ve made countless visits to the doctor and made to feel like I’m wasting their time with my list of symptoms. After doing a menopause symptom checker and having at least 21 symptoms it dawned on me that maybe the doctors had been “missing” the what seemed obvious signs.
        I called my surgery and a very helpful nurse, after some questions, had no hesitation in prescribing me with oestrogen patches. I’m almost 2 weeks in and I’ve just noticed that my concentration seems to have improved a little. Let’s hope it’s the start of getting me back!
        Love to all going through this difficult stage in our lives x

        1. Jo Boyne says:

          So glad that you got some help. But yes, it does seem that we have to shout to be heard when we want our menopause helped by these drugs. I truly hope that the only way is up for you now!

          1. Tanya says:

            Hi Jo,
            Thank you for your kind words x

  3. Samantha Robertson says:

    Hi. This is a great article. I don’t feel so alone. I’ve been peri-menpausal for some time now with no real issues. However a few weeks ago my world suddenly changed. I woke up one morning, burst into tears and haven’t really stopped. Between my teary outburst I’m also angry and frustrated. I can’t talk to people civilly and i stopped answering my phone. The sudden onset of constant body temperature extremes were also making me grumpy. Eventually my friends stopped calling and while i get why they have i wish they would be a bit more understanding. Anyway add this to my brain fog and lack of motivation and interest i decided that i would see my GP. After a long teary session he decided to put me on HRT immediately. I started today and while i obviously haven’t felt any effects I’m filled with hope that this is the answer and i can contact some friends and rebuild. Ha. This post turned out more dramatic than i intended but i never for a second thought that menopause would totally change me into the person i never wanted to be and i won’t let it define me. Thank you again your article has given me some hope.

    1. Jo Boyne says:

      Thank you Samantha. Can totally relate, because I truly turned into someone I hated. I do hope HRT helps you as much as it has helped me.

  4. Emma says:

    Took me 3 years to get a doctor to listen to me as early menopause is in my family. (First visit at (40) Long story short I’ve been on HRT tablets for 2 years 8 months. It’s just been changed to patch and progesterone evening tablets as my joints ached all the time, constantly tired, then I would crash under exhaustion! My physio thought it could be fibromyalgia or myofacial pain syndrome. She told me to go see my GP for a referral to a rheumatologist. GP started asking loads of questions including my recent UTI (never had one before) that I had x2 rounds of antibiotics, still had symptoms, my aura migraines were changing, etc, she said I think it’s your oestrogen levels have dropped and your current HRT is a low dose. Fast forward a week achy joints gone! The urgency to pee is slowly going, tiredness I can now cope. I can’t wait to see how I feel in a months time. Hopefully I’ll go back to weight training very soon as this had to stop due to the aches and exhaustion. Hormones, don’t underestimate them and keep going back to the GP with diaries

    1. Jo Boyne says:

      This is fabulous advice! I think keeping a diary whatever symptoms you have is a great idea. And you have to advocate for yourself, so making notes of all the questions you need to ask is so important!

  5. samantha kear says:

    I had been taking the combined pill for years and years and I suddenly stopped to have my veins treated. I felt wonderful for a few months and then woke up one morning with severe palpitations, felt restless and the anxiety, well I had never experienced these symptoms before. Everything below felt like it was falling out, I had a UTI, periods irregular, brain fog, was agitated and short tempered and also memory loss and many other symptoms, I thought it was the start of Alzheimer’s. It is a worrying time. My doctors were very supportive, I had numerous tests, all clear. Then I watched Davina McCall and started my own research, and realised that maybe I wasn’t losing my mind and actually it was an imbalance of my hormones. I have been prescribed hrt patches its only been two days and obviously the big question “how long until I notice it is working” your article has been very helpful. Fingers crossed my anxiousness and irregular periods will fade as the weeks on hrt take full effect.

    1. Jo Boyne says:

      Thank you for reading and I do hope that things do settle down with the HRT for you. I think the Davina program just hifghlighted the fact that we really do need to advocate for our own care so much these days. And this can be tough when we have so many symptoms and things changing within our own bodies that may feel overwhelming.


Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.